Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis.

نویسندگان

  • Kaei Nasu
  • Masakazu Nishida
  • Yukie Kawano
  • Akitoshi Tsuno
  • Wakana Abe
  • Akitoshi Yuge
  • Noriyuki Takai
  • Hisashi Narahara
چکیده

Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized as a condition in which ectopic endometrial cells exhibit abnormal proliferative and apoptotic regulation in response to appropriate stimuli. Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that, in healthy women, endometrial cells expelled during menstruation do not survive in ectopic locations because of programmed cell death, while decreased apoptosis may lead to the ectopic survival and implantation of these cells, resulting in the development of endometriosis. Both the inability of endometrial cells to transmit a "death" signal and the ability of endometrial cells to avoid cell death have been associated with increased expression of antiapoptotic factors and decreased expression of preapoptotic factors. Further investigations may elucidate the role of apoptosis-associated molecules in the pathogenesis of endometriosis. Medical treatment with apoptosis-inducing agents may be novel and promising therapeutic strategy for endometriosis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-219: The Role of E-Cadherin Coding Gene (CDH1) in Pathogenesis of Endometriosis

Background: Endometriosis, a gyncological disorder,benign and common cause of infertility, is defined as the presence of endometrial glands and stroma at ectopic locations outside the uterine cavity. Clinical observations have led to the assessment that endometriosis is an invasive disease. Abnormal expression of adhesion molecules such as cadherins is likely to be an important determinant of l...

متن کامل

Deregulation of Stemness-Related Genes in Endometriotic Mesenchymal Stem Cells: Further Evidence for Self-Renewal/Differentiation Imbalance

Background: Any irregularities in self-renewal/differentiation balance in endometriotic MSCs can change their fate and function, resulting in endometriosis development. This study aimed to evaluate the expression of OCT4 transcripts (OCT4A, OCT4B, and OCT4B1), SOX2, and NANOG in endometriotic MSCs to show their aberrant expression and to support self-renewal/differentiation imbalance in these c...

متن کامل

P-171: Expression of Vascular Endothelial Growth Factor Receptors In Endometriosis

Background: Endometriosis is a disease which is defined by the growth of endometrium-like tissue outside of the uterine cavity. Literatures show that VEGF by interaction with their receptors, Flt-1 (Fms-like tyrosine kinase-1 or VEGFR-1) and Flk-1/KDR (fetal liver kinase/ kinase-insert domain receptor or VEGFR-2) is related to pathogenesis of endometriosis. The purpose of this study was to eval...

متن کامل

I-28: Role of Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Ki nase-Mediated Signaling Pathway in The Pathogenesis of Endometriosis-Associated Fibrosis

Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...

متن کامل

O-29: Aberrant Methylation of Lysine 9 on Histone 3 in PII Promoter of CYP19A1 Gene in Women with Endometriosis

Background Cytochrome aromatase p450, encoded by the gene CYP19A1, is a key enzyme for estrogen biosynthesis. Among the multiple promoters of CYP19A1, the proximal promoter PII is the most active ones in ovary and endometrium. Endometriosis is a chronic estrogen dependent gynecological condition characterized by the presence of ectopic glands and stroma outside the uterine cavity. Recently, evi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Reproductive sciences

دوره 18 3  شماره 

صفحات  -

تاریخ انتشار 2011